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Relative Humidity Induced Glass Transition Temperature

Relative humidity strongly affects the glass transition temperature (Tg) of amorphous compounds, influencing stability, performance, and shelf life. Water acts as a plasticizer, potentially triggering phase transitions in pharmaceutical powders. Techniques like DVS and iGC enable detailed moisture analysis, hygroscopicity testing, and mapping of amorphous-to-crystalline transitions in APIs.

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Process Optimization Areas

Tg–Humidity Mapping

Define how glass transition temperature shifts with relative humidity. Mapping Tg as a function of moisture content enables identification of critical thresholds where materials transition from stable to mobile states.

Moisture Plasticization Effects

Quantify how water acts as a plasticizer in amorphous systems. Understanding plasticization behavior helps predict changes in mechanical properties, stability, and performance under humid conditions.

Amorphous–Crystalline Transitions

Monitor phase changes triggered by humidity exposure. Identifying conditions that promote recrystallisation supports improved control of processing, storage, and formulation stability.

Kinetics of Glass Transition

Determine the rate at which materials respond to changes in humidity. Kinetic analysis reveals how quickly Tg-related transformations occur, informing handling and processing timelines.

Shelf-Life & Storage Optimization

Link Tg behaviour to long-term stability and product shelf-life. Understanding humidity-driven transitions informs packaging selection and environmental control strategies.

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