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Amorphous Content Determination

Amorphous materials present difficulties associated with the processing, storage, and performance of the product. They have unique properties to their crystalline counterparts, and while amorphous content may be desired, it can also be generated during the processing of different solids via milling, spray drying, or wet granulation.

Less than 10% of an amorphous material can have a profound impact on the overall properties of a product. With DVS, researchers can gain a full understanding of how much amorphous material is present.

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Process Optimization Areas

Moisture Sorption & Hygroscopicity

Quantify how amorphous content influences moisture uptake and stability using DVS and iGC. Gravimetric vapor sorption provides the most sensitive sorption isotherms and kinetic measurements, enabling detection of low levels of amorphous material, supporting optimization of processing conditions and prediction of shelf-life performance.

 

Surface Energy & Powder Interactions

Characterize surface heterogeneity and energy distributions with iGC. Understanding dispersive and acid–base surface properties enable optimization of powder flow, blending, and adhesion, critical for improving formulation performance and consistency.

 

Environmental & Stability Profiling

Simulate real-world storage and handling conditions using controlled humidity and temperature cycling. Sorption-desorption studies provide insight into hysteresis, structural changes, and long-term stability, guiding packaging and environmental control strategies.

 

Glass Transition & Stability Analysis

Evaluate the impact of moisture and temperature on glass transition behaviour. Measure glass transition (Tg) shifts under controlled humidity, helping define important processing and storage conditions to maintain physical stability.

 

Amorphous Content Quantification

Detect and quantify low levels of amorphous material through combined DVS and iGC analysis. SMS techniques provide early identification of process-induced disorder and supporting tighter control of manufacturing conditions.

 

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